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Acceptance and commitment therapy for adults with advanced cancer (CanACT): A feasibility randomised controlled trial

Serfaty, M; Armstrong, M; Vickerstaff, V; Davis, S; Gola, A; McNamee, P; Omar, RZ; ... Low, JTS; + view all (2019) Acceptance and commitment therapy for adults with advanced cancer (CanACT): A feasibility randomised controlled trial. Psycho-Oncology , 28 (3) pp. 488-496. 10.1002/pon.4960. Green open access

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Abstract

OBJECTIVE: To understand the feasibility of recruiting people with advanced cancer into a randomised controlled trial of Acceptance and Commitment therapy (ACT) vs a standardised Talking Control (TC) and delivering ACT to this population; to explore the acceptability of outcome measures and generate normative data. METHODS: This was a feasibility two-arm randomised controlled trial. Participants were attendees with advanced cancer at one of three hospice-based day- therapy units in London, UK, who demonstrated low scores on the Functional Assessment of Cancer Therapies - General (FACT-G). The primary end point was three months. RESULTS: The recruitment target was 54 participants; 42 people were recruited and randomised to up to eight individual sessions of ACT (n=20) or TC (n=22). 18/42 (43%) of participants completed the primary outcome at three months, and at least one follow-up was available in 30/42 (71%) participants. An exploratory analysis revealed a non-significant adjusted mean difference after three months in the main outcome FACT-G of -3.41 (CI= -18.61, 11.79) with TC having better functioning. Over six months the adjusted mean difference between trial arms was 2.25 (CI= -6.03, 10.52) in favour of ACT. CONCLUSIONS: It is feasible to recruit people with advanced cancer in a trial of ACT versus TC. Future research should test the effectiveness of ACT in a fully powered trial.

Type: Article
Title: Acceptance and commitment therapy for adults with advanced cancer (CanACT): A feasibility randomised controlled trial
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/pon.4960
Publisher version: https://doi.org/10.1002/pon.4960
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cancer, oncology, palliative, feasibility, randomised controlled trial, acceptance and commitment therapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10063897
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