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Prediction of the antibacterial activity of garlic extract on E. coli, S. aureus and B. subtilis by determining the diameter of the inhibition zones using artificial neural networks

Atsamnia, D; Hamadache, M; Hanini, S; Benkortbi, O; Oukrif, D; (2017) Prediction of the antibacterial activity of garlic extract on E. coli, S. aureus and B. subtilis by determining the diameter of the inhibition zones using artificial neural networks. LWT - Food Science and Technology , 82 pp. 287-295. 10.1016/j.lwt.2017.04.053. Green open access

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Abstract

The aim of this study was to devise a model that predicts the inhibition zone diameter using artificial neural networks. The concentration, temperature and the exposure time of our extract were taken as input variables. The neural architecture model 3-13-3 and a learning algorithm Quasi-Newton (BFGS) revealed a positive correlation between the experimental results and those artificially predicted, which were measured according to a mean squared error (RMSE) and an R2 coefficient of E. coli (RMSE = 1.28; R2 = 0,96), S. aureus (RMSE = 1.46; R2 = 0,97) and B. subtilis (RMSE = 1.88; R2 = 0,96) respectively. Based on these results, an external and an internal model validation were attained. A neuronal mathematical equation was created to predict the inhibition diameters for experimental data not included in the basic learning. Consequently, a good correlation was observed between the values predicted by the equation and those obtained experimentally, as demonstrated by the R2 and RMSE values. The results regarding the sensitivity analysis showed that the concentration was the most determinant parameter compared to Temperature and Time variables. Ultimately, the model developed in this study will be used reliably to predict the variation of garlic extract's inhibition diameter.

Type: Article
Title: Prediction of the antibacterial activity of garlic extract on E. coli, S. aureus and B. subtilis by determining the diameter of the inhibition zones using artificial neural networks
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.lwt.2017.04.053
Publisher version: http://doi.org/10.1016/j.lwt.2017.04.053
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Inhibition diameter, Bacterial strain, Neural networks, Prediction, Validation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
URI: https://discovery.ucl.ac.uk/id/eprint/10063872
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