Davies, G-L;
Kramberger, I;
Davis, JJ;
(2013)
Environmentally responsive MRI contrast agents.
Chemical Communications
, 49
(84)
pp. 9704-9721.
10.1039/c3cc44268c.
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Abstract
Biomedical imaging techniques can provide a vast amount of anatomical information, enabling diagnosis and the monitoring of disease and treatment profile. MRI uniquely offers convenient, non-invasive, high resolution tomographic imaging. A considerable amount of effort has been invested, across several decades, in the design of non toxic paramagnetic contrast agents capable of enhancing positive MRI signal contrast. Recently, focus has shifted towards the development of agents capable of specifically reporting on their local biochemical environment, where a switch in image contrast is triggered by a specific stimulus/biochemical variable. Such an ability would not only strengthen diagnosis but also provide unique disease-specific biochemical insight. This feature article focuses on recent progress in the development of MRI contrast switching with molecular, macromolecular and nanoparticle-based agents.
| Type: | Article |
|---|---|
| Title: | Environmentally responsive MRI contrast agents |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c3cc44268c |
| Publisher version: | https://doi.org/10.1039/c3cc44268c |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, MESOPOROUS SILICA NANOPARTICLES, TEMPERATURE-SENSITIVE LIPOSOMES, GADOLINIUM-BASED CONTRAST, RESONANCE-IMAGING AGENTS, SATURATION-TRANSFER CEST, MAGNETIC-RESONANCE, HIGH-RELAXIVITY, IN-VIVO, PARAMAGNETIC LIPOSOMES, WATER EXCHANGE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10063839 |
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