UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Neurocritical Care Management of Hepatic Encephalopathy and Coma in Liver Failure

Kerbert, AJ; Engelmann, C; Jalan, R; (2018) Neurocritical Care Management of Hepatic Encephalopathy and Coma in Liver Failure. Seminars in Respiratory and Critical Care Medicine , 39 (5) pp. 523-537. 10.1055/s-0038-1672180.

[img] Text
Jalan_Neurocritical Care Management of Hepatic Encephalopathy and Coma in Liver Failure_AAM.pdf - Accepted version
Access restricted to UCL open access staff until 29 November 2019.

Download (545kB)

Abstract

Hepatic encephalopathy (HE) is a severe complication of liver disease, describing a spectrum of neurological and psychiatric abnormalities ranging from subclinical alterations to coma. HE is the leading cause for hospital readmission, intensive care treatment, and mortality in patients with chronic liver disease. The complex and multifaceted pathogenesis is not yet fully understood, but hypotheses focus on ammonia and systemic inflammation, which are the main targets for currently available therapies in clinical practice. Nevertheless, the remaining high clinical relevance and healthcare burden of this syndrome underlines the emergence for further unraveling the full spectrum of pathomechanisms, as this provides the basis for the development of novel, highly targeted therapies. In this review, the most recent literature about current and future therapies for HE, relevant for intensive care management, will be discussed.

Type: Article
Title: Neurocritical Care Management of Hepatic Encephalopathy and Coma in Liver Failure
Location: United States
DOI: 10.1055/s-0038-1672180
Publisher version: http://dx.doi.org/10.1055/s-0038-1672180
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: hepatic encephalopathy, pathogenesis, classification, diagnosing, treatment
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10063770
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item