UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Semiology, clustering, periodicity and natural history of seizures in an experimental occipital cortical epilepsy model

Chang, B-L; Leite, M; Snowball, A; Lieb, A; Chabrol, E; Walker, MC; Kullmann, DM; ... Wykes, RC; + view all (2018) Semiology, clustering, periodicity and natural history of seizures in an experimental occipital cortical epilepsy model. Disease Models & Mechanisms , 11 (12) , Article dmm036194. 10.1242/dmm.036194. Green open access

[img]
Preview
Text
Chang_Semiology, clustering, periodicity and natural history of seizures in an experimental occipital cortical epilepsy model_VoR.pdf

Download (2MB) | Preview

Abstract

Focal neocortical epilepsy is a common form of epilepsy and there is a need to develop animal models that allow the evaluation of novel therapeutic strategies to treat this type of epilepsy. Tetanus toxin (TeNT) injection into the rat visual cortex induces focal neocortical epilepsy without preceding status epilepticus. The latency to first seizure ranged from 3 to 7 days. Seizure duration was bimodal, with both short (approximately 30 s) and long-lasting (>100 s) seizures occurring in the same animals. Seizures were accompanied by non-motor features such as behavioural arrest, or motor seizures with or without evolution to generalized tonic-clonic seizures. Seizures were more common during the sleep phase of a light-dark cycle. Seizure occurrence was not random, and tended to cluster with significantly higher probability of recurrence within 24 h of a previous seizure. Across animals, the number of seizures in the first week could be used to predict the number of seizures in the following 3 weeks. The TeNT model of occipital cortical epilepsy is a model of acquired focal neocortical epilepsy that is well-suited for preclinical evaluation of novel anti-epileptic strategies. We provide here a detailed analysis of the epilepsy phenotypes, seizure activity, electrographic features and the semiology. In addition, we provide a predictive framework that can be used to reduce variation and consequently animal use in preclinical studies of potential treatments.

Type: Article
Title: Semiology, clustering, periodicity and natural history of seizures in an experimental occipital cortical epilepsy model
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dmm.036194
Publisher version: https://doi.org/10.1242/dmm.036194
Language: English
Additional information: © 2018. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0).
Keywords: Tetanus toxin, Occipital cortical epilepsy, Circadian rhythm, Seizure clustering, Periodic pattern, Prediction
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10063491
Downloads since deposit
69Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item