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Neutrophil Gelatinase-Associated Lipocalin (NGAL) in predicting acute kidney injury following orthotopic liver transplantation: A systematic review

Yeung, ACY; Morozov, A; Robertson, FP; Fuller, BJ; Davidson, BR; (2018) Neutrophil Gelatinase-Associated Lipocalin (NGAL) in predicting acute kidney injury following orthotopic liver transplantation: A systematic review. [Review]. International Journal of Surgery , 59 pp. 48-54. 10.1016/j.ijsu.2018.09.003. Green open access

[thumbnail of Yeung, A. C. Y., Morozov, A., Robertson, F. P., Fuller, B., & Davidson, B. R. Neutrophil Gelatinase Associated Lipocalin following Orthotopic Liver Transplantation. Int J Surg. doi;10.1016.pdf]
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Yeung, A. C. Y., Morozov, A., Robertson, F. P., Fuller, B., & Davidson, B. R. Neutrophil Gelatinase Associated Lipocalin following Orthotopic Liver Transplantation. Int J Surg. doi;10.1016.pdf - Accepted version

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Abstract

Background: Acute kidney injury (AKI) is common after orthotopic liver transplantation (OLT) usually occurring early post-transplant. Multiple causes include graft preservation injury, blood loss, hypotension but also severity of recipient liver disease. Early intervention in AKI has both short and long term patient benefits. Unfortunately there are no current clinical biomarkers of early AKI. Aim: To assess the value of NGAL in predicting AKI following OLT. Methods: Ovid MEDLINE and EMBASE were searched between the years of 2000 and 2017 for studies using keywords: Neutrophil Gelatinase Associated Lipocalin or NGAL variants combined with synonyms for liver transplantation. Results: 96 studies were identified. 11 studies including 563 patients were considered suitable for analysis. Both urinary (uNGAL) and plasma NGAL (pNGAL) measurement were found to predict AKI after liver transplantation. Optimal reported area under the receiver-operator characteristics curve (AUROC) values of 0.5–0.83 and 0.54–0.86 respectively. Conclusions: NGAL is a good predictor of early AKI post OLT although there is considerable variation in the published results. Further studies with prospectively defined cut-off values, standardized definitions of AKI and rigorous data reporting should be conducted to establish its clinical usefulness and limitations.

Type: Article
Title: Neutrophil Gelatinase-Associated Lipocalin (NGAL) in predicting acute kidney injury following orthotopic liver transplantation: A systematic review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijsu.2018.09.003
Publisher version: https://doi.org/10.1016/j.ijsu.2018.09.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Liver transplantation, Acute kidney injury (AKI), Biomarkers, Neutrophil Gelatinase-Associated Lipocalin (NGAL)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10063404
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