UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

An update on advances in magnetic resonance imaging of multiple system atrophy

Chelban, V; Bocchetta, M; Hassanein, S; Haridy, NA; Houlden, H; Rohrer, JD; (2019) An update on advances in magnetic resonance imaging of multiple system atrophy. Journal of Neurology , 266 (4) pp. 1036-1045. 10.1007/s00415-018-9121-3. Green open access

[thumbnail of Chelban2018_Article_AnUpdateOnAdvancesInMagneticRe.pdf]
Preview
Text
Chelban2018_Article_AnUpdateOnAdvancesInMagneticRe.pdf - Published Version

Download (1MB) | Preview

Abstract

In this review, we describe how different neuroimaging tools have been used to identify novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the main structural MRI changes frequently associated with MSA including the 'hot cross-bun' and 'putaminal rim' signs as well as putaminal, pontine, and middle cerebellar peduncle (MCP) atrophy. We discuss the sensitivity and specificity of different supra- and infratentorial changes in differentiating MSA from other disorders, highlighting those that can improve diagnostic accuracy, including the MCP width and MCP/superior cerebellar peduncle (SCP) ratio on T1-weighted imaging, raised putaminal diffusivity on diffusion-weighted imaging, and increased T2* signal in the putamen, striatum, and substantia nigra on susceptibility-weighted imaging. Second, we focus on recent advances in structural and functional MRI techniques including diffusion tensor imaging (DTI), resting-state functional MRI (fMRI), and arterial spin labelling (ASL) imaging. Finally, we discuss new approaches for MSA research such as multimodal neuroimaging strategies and how such markers may be applied in clinical trials to provide crucial data for accurately selecting patients and to act as secondary outcome measures.

Type: Article
Title: An update on advances in magnetic resonance imaging of multiple system atrophy
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00415-018-9121-3
Publisher version: https://doi.org/10.1007/s00415-018-9121-3
Language: English
Additional information: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Imaging, MRI, Multiple system atrophy, Neurodegeneration
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10063390
Downloads since deposit
131Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item