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Globally Efficient Brain Organization and Treatment Response in Psychosis: A Connectomic Study of Gyrification

Palaniyappan, L; Marques, TR; Taylor, H; Mondelli, V; Reinders, AATS; Bonaccorso, S; Giordano, A; ... Dazzan, P; + view all (2016) Globally Efficient Brain Organization and Treatment Response in Psychosis: A Connectomic Study of Gyrification. Schizophrenia Bulletin , 42 (6) pp. 1446-1456. 10.1093/schbul/sbw069. Green open access

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Abstract

BACKGROUND: Converging evidence suggests that patients with first-episode psychosis who show a poor treatment response may have a higher degree of neurodevelopmental abnormalities than good Responders. Characterizing the disturbances in the relationship among brain regions (covariance) can provide more information on neurodevelopmental integrity than searching for localized changes in the brain. Graph-based connectomic approach can measure structural covariance thus providing information on the maturational processes. We quantified the structural covariance of cortical folding using graph theory in first-episode psychosis, to investigate if this systems-level approach would improve our understanding of the biological determinants of outcome in psychosis. METHODS: Magnetic Resonance Imaging data were acquired in 80 first-episode psychosis patients and 46 healthy controls. Response to treatment was assessed after 12 weeks of naturalistic follow-up. Gyrification-based connectomes were constructed to study the maturational organization of cortical folding. RESULTS: Nonresponders showed a reduction in the distributed relationship among brain regions (high segregation, poor integration) when compared to Responders and controls, indicating a higher burden of aberrant neurodevelopment. They also showed reduced centrality of key regions (left insula and anterior cingulate cortex) indicating a marked reconfiguration of gyrification. Nonresponders showed a vulnerable pattern of covariance that disintegrated when simulated lesions removed high-degree hubs, indicating an abnormal dependence on highly central hub regions in Nonresponders. CONCLUSIONS: These findings suggest that a perturbed maturational relationship among brain regions underlies poor treatment response in first-episode psychosis. The information obtained from gyrification-based connectomes can be harnessed for prospectively predicting treatment response and prognosis in psychosis.

Type: Article
Title: Globally Efficient Brain Organization and Treatment Response in Psychosis: A Connectomic Study of Gyrification
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/schbul/sbw069
Publisher version: https://doi.org/10.1093/schbul/sbw069
Language: English
Additional information: © The Author 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: cortical folding, connectome, graph theory, neuroimaging, first-episode psychosis, surface based morphometry
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10063338
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