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Under crossfire: thromboembolic risk in systemic lupus erythematosus

Ramirez, GA; Efthymiou, M; Isenberg, DA; Cohen, H; (2019) Under crossfire: thromboembolic risk in systemic lupus erythematosus. Rheumatology , 58 (6) pp. 940-952. 10.1093/rheumatology/key307. Green open access

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Abstract

Cerebral and cardiovascular ischaemic events are frequent complications of SLE and constitute primary causes of permanent damage. However, the pathogenic determinants of an increased thromboembolic risk in patients with SLE are only partially understood. Atherosclerosis constitutes fertile soil for the development of thrombosis and shows disproportionately high prevalence and progression rates in patients with SLE. aPLs are independent risk factors for acute thrombosis but can also prompt long-term vascular inflammation. Aberrant interactions among immune cells and dysfunctions in the deployment of the coagulation cascade have historically been less explored in SLE, but recent evidence suggests they can also play a critical role at the crossroads between inflammation and haemostasis. In this review we discuss how different prothrombotic mechanisms can be prompted by and synergize with SLE-specific pathogenic events and speculate about novel potential directions for research and drug development.

Type: Article
Title: Under crossfire: thromboembolic risk in systemic lupus erythematosus
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/rheumatology/key307
Publisher version: https://doi.org/10.1093/rheumatology/key307
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: antiphospholipid antibodies, atherosclerosis, cardiovascular risk, coagulation, innate immunity, ischaemia, protein C, systemic lupus erythematosus, thromboembolism, thrombosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10063289
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