Shawcross, A;
Murray, C;
Pike, KC;
Horsley, A;
(2019)
A novel method for infant multiple breath washout: first report in clinical practice.
Pediatric Pulmonology
, 54
(8)
pp. 1284-1290.
10.1002/ppul.24384.
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Abstract
BACKGROUND: Lung clearance index (LCI), measured using multiple breath inert gas washout (MBW) is a potentially useful test in infants with respiratory disease, particularly cystic fibrosis (CF). Clinical use is limited however by the need for specialist staff and equipment. We have previously described a novel method for infant MBW suitable for use outside of specialist laboratories. This study describes its performance in vivo in infants with CF and healthy controls, including a limited comparison with the respiratory mass spectrometer. METHODS: Children aged <2 years with CF and controls underwent MBW testing on a single occasion. Practical applicability of the system was determined by the number of successful duplicate tests, and within-subject repeatability. RESULTS: 25 children (7 with CF, 18 healthy controls, all sedated with chloral hydrate) attempted MBW. 20 patients (7 with CF) successfully underwent duplicate testing (80% success rate). Mean within-subject coefficient of variation for FRC was 7.2% and for LCI 5.9%. Comparison of LCI with the mass spectrometer was limited . but gave very similar values for LCI and FRC in those patients who underwent technically adequate tests with both methods. CONCLUSION: We have described a new MBW method that is feasible and reproducible in sedated infants. Results fall within the expected range, and well within accuracy limits set by international guidelines. This could provide a more accessible alternative to previously described systems for infant MBW, and overcomes many of the technical challenges inherent in conventional MBW.
| Type: | Article |
|---|---|
| Title: | A novel method for infant multiple breath washout: first report in clinical practice |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ppul.24384 |
| Publisher version: | https://doi.org/10.1002/ppul.24384 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Infant pulmonary function, multiple breath washout, lung clearance index, cystic fibrosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10063219 |
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