Qureshi, MS;
Alsughayyir, J;
Chhabra, M;
Ali, JA;
Goddard, MJ;
Devine, C;
Conlon, T;
... Pettigrew, GJ; + view all
(2019)
Data regarding transplant induced germinal center humoral autoimmunity.
Data in Brief
, 22
pp. 647-657.
10.1016/j.dib.2018.12.078.
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Abstract
This data is related to the research article entitled “Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy” (Harper et al., 2016) [2]. The data presented here focuses on the humoral autoimmune response triggered by transferred allogeneic CD4 T cells and includes details on: (a) the recipient splenic germinal center (GC) response; (b) augmentation of humoral autoimmunity and accelerated heart allograft rejection following transplantation from donors primed against recipient; (c) flow cytometric analysis of donor and recipient CD4 T cells for signature markers of T follicular helper cell differentiation; (d) in vitro donor endothelial cell migration in response to column purified autoantibody from recipient sera; (e) analysis of development of humoral responses in recipients following adoptive transfer of donor CD4 T cells and; (f) the development of humoral autoimmunity in mixed haematopoietic chimeric mice.
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