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Stem Cell Therapies for Retinal Repair and Regeneration (Chapter 12)

Eastlake, K; Wang, W; Lamb, WDB; Limb, GA; (2019) Stem Cell Therapies for Retinal Repair and Regeneration (Chapter 12). RSC Drug Discovery Series (66) pp. 196-215. 10.1039/9781788013666-00196. Green open access

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Abstract

Neural cell damage is the main feature of retinal degenerative disorders and constitutes the major cause of blindness in patients affected by retinal disease. Present treatments aim to prevent disease progression but do not reverse lost vision, for which stem cell-based therapies are the only hope for restoration or maintenance of visual function in individuals affected by severe disease. This chapter summarizes recent progress in the stem cell field and describes advances made on the clinical application of these cells for treatment of retinal degeneration. In addition, it highlights research being actively pursued to promote endogenous regeneration of the neural retinaas an alternative to transplantation.

Type: Article
Title: Stem Cell Therapies for Retinal Repair and Regeneration (Chapter 12)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/9781788013666-00196
Publisher version: http://doi.org/10.1039/9781788013666-00196
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: retina, embryonic stem cells, induced pluripotent stem cells, tissue specific stem cells, Müller cells; retinal ganglion cells; retinal degeneration; transplantation; neurotrophins.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10062868
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