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The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer

Gootjes, EC; Bakkerus, L; ten Tije, AJ; Witteveen, PO; Buffart, TE; Bridgewater, JA; Primrose, JN; ... Verheul, HMW; + view all (2018) The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer. European Journal of Cancer Prevention , 103 pp. 160-164. 10.1016/j.ejca.2018.07.012. Green open access

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Abstract

Local treatment of metastases by surgical resection or other ablative therapies is technically feasible in an increasing number of patients with multi-organ metastatic cancer. This results in a growing debate on whether patients with extensive disease, that is traditionally deemed unresectable, may benefit from local treatment of metastases when added to standard palliative systemic therapy. For selected patients with oligometastatic colorectal cancer, local treatment of metastases has become the standard of care based on retrospective reports showing long-term survival rates. In addition to systemic therapy, preliminary evidence suggests that patients with extensive metastatic colorectal cancer may also benefit from local treatment. Here, we present the future perspectives based on the available literature on local treatment approaches in colorectal cancer.

Type: Article
Title: The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ejca.2018.07.012
Publisher version: https://doi.org/10.1016/j.ejca.2018.07.012
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Colorectal carcinoma, Tumour debulking, Extrahepatic disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10062650
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