Adler, S;
Hong, S-J;
Liu, M;
Baldeweg, T;
Cross, JH;
Bernasconi, A;
Bernhardt, BC;
(2018)
Topographic principles of cortical fluid-attenuated inversion recovery signal in temporal lobe epilepsy.
Epilepsia
, 59
(3)
pp. 627-635.
10.1111/epi.14017.
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Abstract
Objective: In drug‐resistant temporal lobe epilepsy (TLE), relative to the large number of whole‐brain morphological studies, neocortical T2 changes have not been systematically investigated. The aim of this study was to assess the anatomical principles that govern the distribution of neocortical T2‐weighted fluid‐attenuated inversion recovery (FLAIR) signal intensity and uncover its topographic principles. Methods: Using a surface‐based sampling scheme, we mapped neocortical FLAIR intensity of 61 TLE patients relative to 38 healthy controls imaged at 3 T. To address topographic principles of the susceptibility to FLAIR signal changes in TLE, we assessed associations with normative data on tissue composition using 2 complementary approaches. First, we evaluated whether the degree of TLE‐related FLAIR intensity changes differed across cytoarchitectonic classes as defined by Von Economo‐Koskinas taxonomy. Second, as a proxy to map regions with similar intracortical composition, we carried out a FLAIR intensity covariance paradigm in controls by seeding systematically from all cortical regions, and identified those networks that were the best spatial predictors of the between‐group FLAIR changes. Results: Increased intensities were observed in bilateral limbic and paralimbic cortices (hippocampus, parahippocampus, cingulate, temporopolar, insular, orbitofrontal). Effect sizes were highest in periallocortical limbic and insular classes as defined by the Von Economo‐Koskinas cytoarchitectonic taxonomy. Furthermore, systematic FLAIR intensity covariance analysis in healthy controls revealed that similarity patterns characteristic of limbic cortices, most notably the hippocampus, served as sensitive predictors for the topography of FLAIR hypersignal in patients. FLAIR intensity findings were robust against correction for morphological confounds. Patients with a history of febrile convulsions showed more marked signal changes in parahippocampal and retrosplenial cortices, known to be strongly connected to the hippocampus. Significance: FLAIR intensity mapping and covariance analysis provide a model of TLE gray matter pathology based on shared vulnerability of periallocortical and limbic cortices.
| Type: | Article |
|---|---|
| Title: | Topographic principles of cortical fluid-attenuated inversion recovery signal in temporal lobe epilepsy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/epi.14017 |
| Publisher version: | http://doi.org/10.1111/epi.14017 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | covariance analysis, hippocampus, magnetic resonance imaging, temporal lobe epilepsy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10062208 |
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