Hatton, GB;
Madla, CM;
Rabbie, SC;
Basit, AW;
(2018)
Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption.
Drug Discovery Today
, 24
(2)
pp. 417-427.
10.1016/j.drudis.2018.11.009.
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Abstract
It was in 400 BC that Hippocrates reportedly stated that "death sits in the colon". The growth in our knowledge of the intestinal microbiome and the gut-brain axis, their function and imbalance, has distinctly uncovered the complex relationship between the gut to disease predisposition and development, heralding the problem and the solution to disease pathology. Human studies of new drug molecules are typically performed in healthy volunteers and their specific disease indication. Approved drugs, however, are used by patients with diverse disease backgrounds. Here, we review the current literature of the gastrointestinal tract reacting to systemic disease pathology that elicits physiological and functional changes that consequently affect oral drug product performance.
| Type: | Article |
|---|---|
| Title: | Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.drudis.2018.11.009 |
| Publisher version: | https://doi.org/10.1016/j.drudis.2018.11.009 |
| Language: | English |
| Additional information: | Copyright © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Cystic fibrosis, HIV, Parkinson’s disease, diabetes, oral drug products, pain |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10062128 |
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