Butcher, EJ;
Dezateux, C;
Knowles, R;
(2019)
Risk factors for permanent childhood hearing impairment.
Archives of Disease in Childhood: Fetal & Neonatal
10.1136/archdischild-2018-315866.
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Abstract
OBJECTIVES: While several perinatal risk factors for permanent childhood hearing impairment (PCHI) are known, association with gestational length remains unclear. We hypothesised that shorter gestational length predicts higher PCHI risk. // DESIGN: 19504 participants from UK Millennium Cohort Study (born 2000-2002, prior to newborn screening). // METHODS: Multivariable discrete-time survival analysis to examine associations between parent-reported PCHI by age 11 years and gestational length, plus other pre-specified factors. // RESULTS: PCHI affected 2.1 per 1000 children (95% CI: 1.5-3.0) by age 11, however gestational length did not predict PCHI risk (hazard ratio, 95% CI: 1.00, 0.98-1.03 per day increase). Risk was increased in those with neonatal illness, with or without admission to neonatal care (6.33, 2.27-17.63 and 2.62, 1.15-5.97, respectively), of Bangladeshi or Pakistani ethnicity (2.78, 1.06-7.31), or born to younger mothers (0.92, 0.87-0.97 per year). // CONCLUSION: Neonatal illness, rather than gestational length, predicts PCHI risk. Further research should explore associations with ethnicity.
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