UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population

Stierli, S; Napoli, I; White, IJ; Cattin, A-L; Cabrejos, AM; Calavia, NG; Malong, L; ... Lloyd, AC; + view all (2018) The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population. Development , 145 , Article dev170316. 10.1242/dev.170316. Green open access

[img]
Preview
Text
Richardson_The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population_AOP.pdf

Download (12MB) | Preview

Abstract

Peripheral nerves are highly regenerative in contrast to the poor regenerative capabilities of the CNS. Here we show that adult peripheral nerve is a more quiescent tissue than the CNS, yet all cell-types within a peripheral nerve proliferate efficiently following injury. Moreover, whereas oligodendrocytes are produced throughout life from a precursor pool, we find that the corresponding cell of the PNS, the myelinating Schwann cell (mSC) does not turnover in the adult. However, following injury, all mSCs can dedifferentiate to the proliferating progenitor-like SCs that orchestrate the regenerative response. Lineage analysis shows these newly-migratory, progenitor-like cells redifferentiate to form new tissue at the injury site, maintain their lineage but can switch to become a non-myelinating SC. In contrast, increased plasticity is observed during tumourigenesis. These findings show that peripheral nerves have a distinct mechanism for maintaining homeostasis and can regenerate without the need for an additional stem cell population.

Type: Article
Title: The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1242/dev.170316
Publisher version: https://doi.org/10.1242/dev.170316
Language: English
Additional information: © 2018. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0).
Keywords: CNS, PNS, Schwann cells, Stem cells, Tissue homeostasis, Tissue regeneration
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10061979
Downloads since deposit
54Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item