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Conjunctival allergen provocation test : guidelines for daily practice

Fauquert, J-L; Jedrzejczak-Czechowicz, M; Rondon, C; Calder, V; Silva, D; Kvenshagen, BK; Callebaut, I; ... Leonardi, A; + view all (2016) Conjunctival allergen provocation test : guidelines for daily practice. Allergy , 72 (1) pp. 43-54. 10.1111/all.12986. Green open access

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Abstract

Conjunctival allergen provocation test (CAPT) reproduces the events occurring by instilling an allergen on the ocular surface. This paper is the compilation of a task force focussed on practical aspects of this technique based on the analysis of 131 papers. Main mechanisms involved are reviewed. Indications are diagnosing the allergen(s)‐triggering symptoms in IgE‐mediated ocular allergy in seasonal, acute or perennial forms of allergic conjunctivitis, especially when the relevance of the allergen is not obvious or in polysensitized patients. Contraindications are limited to ongoing systemic severe pathology, asthma and eye diseases. CAPT should be delayed if receiving systemic steroids or antihistamines. Local treatment should be interrupted according to the half‐life of each drug. Prerequisites are as follows: obtaining informed consent; evidencing of an allergen by skin prick tests and/or serum‐specific IgE dosages; being able to deal with an unlikely event such as acute asthma exacerbation, urticaria or anaphylaxis, or an exacerbation of allergic conjunctivitis. Allergen extracts should be diluted locally prior to administration. Positive criteria are based on itching or quoted according to a composite score. An alternative scoring is based on itching. CAPT remains underused in daily practice, although it is a safe and simple procedure which can provide valuable clinical information.

Type: Article
Title: Conjunctival allergen provocation test : guidelines for daily practice
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/all.12986
Publisher version: https://doi.org/10.1111/all.12986
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Allergy, Immunology, allergen challenge, conjunctivitis, provocation test, in vivo diagnosis, ocular surface diagnosis, ocular surface, 0.1-PERCENT OPHTHALMIC SOLUTION, OCULAR ALLERGY, CHALLENGE MODEL, EARLY-PHASE, MAST-CELL, IN-VIVO, CLINICAL-TRIALS, IMMUNOTHERAPY, POLLEN, TEAR
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10061636
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