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A Review of the Cytokine IL-17 in Ocular Surface and Corneal Disease

Garbutcheon-Singh, KB; Carnt, N; Pattamatta, U; Samarawickrama, C; White, A; Calder, V; (2019) A Review of the Cytokine IL-17 in Ocular Surface and Corneal Disease. Current Eye Research , 44 (1) pp. 1-10. 10.1080/02713683.2018.1519834. Green open access

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Abstract

AIM: To investigate the role of interleukin-17 in ocular surface and corneal disease. Ocular surface and corneal disease is a leading cause of blindness and is an ongoing challenge for the public health sector to implement effective therapies. The majority of cells in corneal lesions are derived primarily from neutrophils that induce inflammatory events that lead to tissue damage. One of the key pro-inflammatory cytokines is IL-17, and it has been investigated in order to facilitate the understanding of the pathogenesis of ocular surface lesion development. METHOD: A review of the literature was performed through a systematic approach. RESULTS: IL-17 has been shown to exacerbate dry eye disease, viral and bacterial keratitis lesion severity, although it was found to be protective for Acanthamoeba. Antibodies developed to neutralize IL-17 have shown some promise in reducing the severity of some diseases. CONCLUSION: IL-17 plays a role in the pathogenesis of ocular surface and corneal disease and targeting this cytokine may provide a useful treatment option in the future.

Type: Article
Title: A Review of the Cytokine IL-17 in Ocular Surface and Corneal Disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/02713683.2018.1519834
Publisher version: https://doi.org/10.1080/02713683.2018.1519834
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Keratitis, bacterial, dry eye, fungal, herpes simplex, ocular surface and corneal disease, viral Acanthamoeba
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10061629
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