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Super-Resolved Traction Force Microscopy (STFM)

Colin-York, H; Shrestha, D; Felce, JH; Waithe, D; Moeendarbary, E; Davis, SJ; Eggeling, C; (2016) Super-Resolved Traction Force Microscopy (STFM). Nano Letters , 16 (4) pp. 2633-2638. 10.1021/acs.nanolett.6b00273. Green open access

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Abstract

Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution and accuracy of force reconstruction of the well-established technique of traction force microscopy (TFM) using STED microscopy. The increased spatial resolution of STED-TFM (STFM) allows a greater than 5-fold higher sampling of the forces generated by the cell than conventional TFM, accessing the nano instead of the micron scale. This improvement is highlighted by computer simulations and an activating RBL cell model system.

Type: Article
Title: Super-Resolved Traction Force Microscopy (STFM)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.nanolett.6b00273
Publisher version: https://doi.org/10.1021/acs.nanolett.6b00273
Language: English
Additional information: This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Keywords: actin cytoskeleton; mechanobiology; Super-resolution microscopy; traction force microscopy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10061339
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