UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Modified cantilever arrays improve sensitivity and reproducibility of nanomechanical sensing in living cells

Patil, SB; Al-Jehani, RM; Etayash, H; Turbe, V; Jiang, K; Bailey, J; Al-Akkad, W; ... Ndieyira, JW; + view all (2018) Modified cantilever arrays improve sensitivity and reproducibility of nanomechanical sensing in living cells. Communications Biology , 1 , Article 175. 10.1038/s42003-018-0179-3. Green open access

[thumbnail of Article]
Preview
Text (Article)
McKendry_s42003-018-0179-3.pdf - Published Version

Download (2MB) | Preview
[thumbnail of Supplementary information]
Preview
Text (Supplementary information)
McKendry_42003_2018_179_MOESM1_ESM.pdf - Published Version

Download (745kB) | Preview

Abstract

Mechanical signaling involved in molecular interactions lies at the heart of materials science and biological systems, but the mechanisms involved are poorly understood. Here we use nanomechanical sensors and intact human cells to provide unique insights into the signaling pathways of connectivity networks, which deliver the ability to probe cells to produce biologically relevant, quantifiable and reproducible signals. We quantify the mechanical signals from malignant cancer cells, with 10 cells per ml in 1000-fold excess of non-neoplastic human epithelial cells. Moreover, we demonstrate that a direct link between cells and molecules creates a continuous connectivity which acts like a percolating network to propagate mechanical forces over both short and long length-scales. The findings provide mechanistic insights into how cancer cells interact with one another and with their microenvironments, enabling them to invade the surrounding tissues. Further, with this system it is possible to understand how cancer clusters are able to co-ordinate their migration through narrow blood capillaries.

Type: Article
Title: Modified cantilever arrays improve sensitivity and reproducibility of nanomechanical sensing in living cells
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s42003-018-0179-3
Publisher version: http://doi.org/10.1038/s42003-018-0179-3
Language: English
Additional information: Copyright © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10061232
Downloads since deposit
155Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item