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Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies

Burt, R; Warcel, D; Fielding, AK; (2019) Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies. Human Vaccines & Immunotherapeutics , 15 (3) pp. 594-602. 10.1080/21645515.2018.1540828. Green open access

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Abstract

Blinatumomab (Blincyto, Amgen), a bi-specific antibody, is a first-in-class, targeted immunotherapy agent for treatment of B-cell malignancies with a novel mechanism of action which involves in-vivo engagement of the patient's T cells with CD19-expressing tumour cells. Clinical trials have demonstrated its efficacy in relapsed B-cell Acute Lymphoblastic Leukaemia (B-ALL) and B-cell Non-Hodgkin's Lymphoma including in patients who are refractory to chemotherapy. This review summarises the development and design of Blinatumomab, the outcome of clinical studies demonstrating its efficacy and how to manage the administration, practically, including relevant toxicities. We compare and contrast it to other emerging agents for treatment of B-cell malignancies.

Type: Article
Title: Blinatumomab, a bispecific B-cell and T-cell engaging antibody, in the treatment of B-cell malignancies
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/21645515.2018.1540828
Publisher version: https://doi.org/10.1080/21645515.2018.1540828
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: B-cell non hodgkin Lymphoma, Blinatumomab, acute lymphoblastic Leukaemia, immunotherapeutics
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10060993
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