Nour, MM;
McCutcheon, R;
Howes, OD;
(2018)
The Relationship Between Dopamine Synthesis Capacity and Release: Implications for Psychosis.
[Letter].
Neuropsychopharmacology
, 43
(6)
pp. 1195-1196.
10.1038/npp.2017.293.
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Abstract
Berry and colleagues report that presynaptic striatal dopamine synthesis capacity (measured with [¹⁸F]FMT PET) is not associated with methylphenidate-induced striatal dopamine release (indexed as a reduction in [¹¹C]raclopride non-displaceable binding-potential) in healthy participants (Berry et al, 2017). The authors should be commended for the quality of this study, in which 40 subjects each received three PET scans within a short time window. The results are pertinent to the interpretation of neuroimaging studies investigating the dopamine hypothesis of schizophrenia.
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