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Structure-based prediction of protein allostery

Greener, JG; Sternberg, MJE; (2018) Structure-based prediction of protein allostery. Current Opinion in Structural Biology , 50 pp. 1-8. 10.1016/j.sbi.2017.10.002. Green open access

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Abstract

Allostery is the functional change at one site on a protein caused by a change at a distant site. In order for the benefits of allostery to be taken advantage of, both for basic understanding of proteins and to develop new classes of drugs, the structure-based prediction of allosteric binding sites, modulators and communication pathways is necessary. Here we review the recently emerging field of allosteric prediction, focusing mainly on computational methods. We also describe the search for cryptic binding pockets and attempts to design allostery into proteins. The development and adoption of such methods is essential or the long-preached potential of allostery will remain elusive.

Type: Article
Title: Structure-based prediction of protein allostery
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.sbi.2017.10.002
Publisher version: https://doi.org/10.1016/j.sbi.2017.10.002
Language: English
Additional information: © 2017 The Authors. This is anopen access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10060289
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