Molloy, SF;
Bradley, J;
Karunaharan, N;
Mputu, M;
Stone, N;
Phulusa, J;
Chawinga, C;
... Harrison, TS; + view all
(2018)
Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.
[Letter].
AIDS
, 32
(15)
pp. 2259-2261.
10.1097/QAD.0000000000001961.
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Abstract
We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: −28 to 46 ms) in the fluconazole treatment group and −12.6 ms (IQR: −39 to 13.5 ms) in those not taking fluconazole (P = 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.
| Type: | Article |
|---|---|
| Title: | Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/QAD.0000000000001961 |
| Publisher version: | http://dx.doi.org/10.1097/QAD.0000000000001961 |
| Language: | English |
| Additional information: | © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10060164 |
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