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The neuropsychopharmacology of cannabis: a review of human imaging studies

Bloomfield, MAP; Hindocha, C; Green, SF; Wall, MB; Lees, R; Petrilli, K; Costello, H; ... Freeman, TP; + view all (2019) The neuropsychopharmacology of cannabis: a review of human imaging studies. Pharmacology & Therapeutics , 195 pp. 132-161. 10.1016/j.pharmthera.2018.10.006. Green open access

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Abstract

The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in cannabis is Δ9-tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB1 receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, reward and memory processing via direct interactions with the endocannabinoid system and indirect effects on the glutamatergic, GABAergic and dopaminergic systems. Cannabidiol, a non-intoxicating cannabinoid found in some forms of cannabis, may offset some of these acute effects. Heavy repeated cannabis use, particularly during adolescence, has been associated with adverse effects on these systems, which increase the risk of mental illnesses including addiction and psychosis. Here, we provide a comprehensive state of the art review on the acute and chronic neuropsychopharmacology of cannabis by synthesizing the available neuroimaging research in humans. We describe the effects of drug exposure during development, implications for understanding psychosis and cannabis use disorder, and methodological considerations. Greater understanding of the precise mechanisms underlying the effects of cannabis may also give rise to new treatment targets.

Type: Article
Title: The neuropsychopharmacology of cannabis: a review of human imaging studies
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pharmthera.2018.10.006
Publisher version: https://doi.org/10.1016/j.pharmthera.2018.10.006
Language: English
Additional information: This version is the author accepted manuscript made available under a Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/) until the published version is available.
Keywords: Addiction, Cannabis, Cognition, Development, Neuroimaging, Psychosis
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10060096
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