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Preclinical and clinical evaluation of the liver tumor irreversible electroporation by magnetic resonance imaging

Figini, M; Wang, X; Lyu, T; Su, Z; Procissi, D; Yaghmai, V; Larson, AC; (2017) Preclinical and clinical evaluation of the liver tumor irreversible electroporation by magnetic resonance imaging. American Journal of Translational Research , 9 (2) pp. 580-590. Green open access

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Abstract

Irreversible electroporation (IRE) is a relatively new technique for tumor ablation. It has shown promising results in difficult cases where surgery is not recommended and delicate anatomic structures are present near or within the tumor. Currently, liver cancer is one of the most common targets for IRE treatment. Pre-operative and post-operative imaging has a key role in IRE procedures and research studies. Although ultrasound is usually the first choice, especially for intra-operative guidance, magnetic resonance imaging (MRI) plays an important role in the visualization and characterization of tumor before and after IRE in clinical and preclinical studies. However, the appearance of liver lesions after IRE with different MRI sequences has never been systematically investigated, and the most common practice is to limit the acquisition protocol to only contrast-enhanced T1-weighted images. In this work, the role of MRI in clinical and preclinical assessment of hepatic tumors treated with IRE is reviewed and discussed.

Type: Article
Title: Preclinical and clinical evaluation of the liver tumor irreversible electroporation by magnetic resonance imaging
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.ajtr.org/files/ajtr0037958.pdf
Language: English
Additional information: AJTR Copyright © 2009-present, all rights reserved. American Journal of Translational Research is an open access journal. Once the paper is published, the copyright will be released by the publisher under the “Creative Commons Attribution Noncommercial License”, enabling the unrestricted non-commercial use, distribution, and reproduction of the published article in any medium, provided that the original work is properly cited.
Keywords: irreversible electroporation, liver, magnetic resonance imaging, therapy response
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10059891
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