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A dual switched-capacitor integrator architecture for versatile, real-time amperometric biosensing

Pligouroudis, M; Papadimitriou, KI; Evans, D; Prodromakis, T; (2017) A dual switched-capacitor integrator architecture for versatile, real-time amperometric biosensing. In: (Proceedings) 2017 IEEE International Symposium on Circuits and Systems (ISCAS). IEEE Green open access

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Abstract

In this paper, a versatile, re-programmable, current-input bioinstrumentation board is presented for electrochemical amperometric measurements. The proposed instrument has been fabricated on a six layer printed circuit board (PCB) and exploits dual switched-capacitor (SC) integration and sample-and-hold (SH) techniques. It comprises off-the-shelf switch and amplifier ICs and a commercially available FPGA-based DSP unit for digital signal control and synchronisation. It features eight amperometric channels, has a dynamic current range of 100dB, can be powered-up by a USB port or a 5V battery and is portable, with dimensions of 110×110 mm2. An onboard digital-to-analog converter (DAC) combined with standard three-electrode potentiostats can provide precise, programmable biasing voltages to eight amperometric biosensors simultaneously. Validation of the robustness and accuracy of the proposed system is demonstrated by proof-of-concept amperometric measurements using a high-precision Keithley 6221 current source and NaCI solution on a PCB-based sensor.

Type: Proceedings paper
Title: A dual switched-capacitor integrator architecture for versatile, real-time amperometric biosensing
Event: 2017 IEEE International Symposium on Circuits and Systems (ISCAS)
ISBN-13: 9781467368520
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ISCAS.2017.8050728
Publisher version: https://doi.org/10.1109/ISCAS.2017.8050728
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: https://discovery.ucl.ac.uk/id/eprint/10059819
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