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Etiologies and characteristics of refractory status epilepticus cases in different areas of the world: Results from a global audit

Ferlisi, M; Hocker, S; Trinka, E; Shorvon, S; International Steering Committee of the StEp Audit, .; (2018) Etiologies and characteristics of refractory status epilepticus cases in different areas of the world: Results from a global audit. Epilepsia , 59 (S2) pp. 100-107. 10.1111/epi.14496. Green open access

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Abstract

To describe the demographics, etiologies, types of status epilepticus (SE), and outcomes in people with refractory and super‐refractory SE from around the world, we prospectively collected cases of refractory SE (RSE) treated with continuous intravenous anesthetic drugs in an intensive care unit setting through online questionnaires using “active surveillance.” We collected information about 776 cases of RSE in 50 countries over 4 years. Control of SE was achieved in 74% of the cases. Neurologic outcomes were poor in 41% of patients, and 24% died. Good outcome was associated with younger age and a history of epilepsy. Etiology strongly influenced the outcome. Patients from Asia were younger, more frequently presented with convulsive SE, and were more frequently affected by infectious etiologies when compared with patients from Europe and the Americas. Despite these differences, outcomes were similar in all countries. Demographics of patients with RSE in a global audit are similar to those in prior single center series, providing evidence of generalizability of those studies. Important differences exist among patients with RSE from different regions of the world, but these do not seem to significantly influence patient outcomes.

Type: Article
Title: Etiologies and characteristics of refractory status epilepticus cases in different areas of the world: Results from a global audit
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/epi.14496
Publisher version: https://doi.org/10.1111/epi.14496
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: etiology, global audit, refractory, registry, status epilepticus, super-refractory
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10059701
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