Cunha, L;
Diekmann, Y;
Kowada, L;
Stoye, J;
(2018)
Identifying Maximal Perfect Haplotype Blocks.
In:
(Proceedings) BSB 2018: Advances in Bioinformatics and Computational Biology.
Springer: Cham.
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Abstract
The concept of maximal perfect haplotype blocks is introduced as a simple pattern allowing to identify genomic regions that show signatures of natural selection. The model is formally defined and a simple algorithm is presented to find all perfect haplotype blocks in a set of phased chromosome sequences. Application to three whole chromosomes from the 1000 genomes project phase 3 data set shows the potential of the concept as an effective approach for quick detection of selection in large sets of thousands of genomes.
| Type: | Proceedings paper |
|---|---|
| Title: | Identifying Maximal Perfect Haplotype Blocks |
| Event: | BSB 2018: Advances in Bioinformatics and Computational Biology |
| Location: | Niteroi, Rio de Janeiro, Brazil |
| Dates: | 30 October 2018 - 01 November 2018 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-030-01722-4_3 |
| Publisher version: | https://doi.org/10.1007/978-3-030-01722-4_3 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10059682 |
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