Quezada, SA;
Peggs, KS;
(2018)
Lost in Translation: Deciphering the mechanism of action of anti-human CTLA-4.
Clinical Cancer Research
10.1158/1078-0432.CCR-18-2509.
(In press).
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Abstract
Despite a number of pre-clinical studies demonstrating that the activity of anti-CTLA-4 antibodies in murine models of cancer relies on effector T cell activation and Treg depletion, the activity of the clinical antibodies remains controversial. To decipher such mechanisms is critical to the development of novel and more potent immunotherapies.
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