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Receptive Field Properties of Koniocellular On/Off Neurons in the Lateral Geniculate Nucleus of Marmoset Monkeys

Eiber, CD; Rahman, AS; Pietersen, ANJ; Zeater, N; Dreher, B; Solomon, SG; Martin, PR; (2018) Receptive Field Properties of Koniocellular On/Off Neurons in the Lateral Geniculate Nucleus of Marmoset Monkeys. Journal of Neuroscience , 38 (48) pp. 10384-10398. 10.1523/JNEUROSCI.1679-18.2018. Green open access

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Abstract

The koniocellular (K) layers of the primate dorsal lateral geniculate nucleus house a variety of visual receptive field types, not all of which have been fully characterized. Here we made single cell recordings targeted to the K layers of diurnal New World monkeys (marmosets). A subset of recorded cells was excited by both increments and decrements of light intensity (on/off-cells). Histological reconstruction of the location of these cells confirmed that they are segregated to K layers; we therefore refer to these cells as K-on/off cells. The K-on/off cells show high contrast sensitivity, strong band-pass spatial frequency tuning, and their response magnitude is strongly reduced by stimuli larger than the excitatory receptive field (silent suppressive surrounds). Stationary counterphase gratings evoke unmodulated spike rate increases or frequency-doubled responses in K-on/off cells; such responses are largely independent of grating spatial phase. The K-on/off cells are not orientation or direction selective. Some (but not all) properties of K-on/off cells are consistent with those of local-edge-detector/impressed-by-contrast cells reported in studies of cat retina and geniculate, and broad-thorny ganglion cells recorded in macaque monkey retina. The receptive field properties of K-on/off cells and their preferential location in the ventral K layers (K1 and K2) make them good candidates for the direct projection from geniculate to extrastriate cortical area MT/V5. If so, they could contribute to visual information processing in the dorsal ("where" or "action") visual stream.SIGNIFICANCE STATEMENTWe characterize cells in a primitive part of the visual pathway in primates. The cells are located in the lateral geniculate nucleus (the main visual afferent relay nucleus), in regions called koniocellular layers that are known to project to extrastriate visual areas as well as primary visual cortex. The cells show high contrast sensitivity and rapid, transient responses to light onset and offset. Their properties suggest they could contribute to visual processing in the dorsal ("where" or "action") visual stream.

Type: Article
Title: Receptive Field Properties of Koniocellular On/Off Neurons in the Lateral Geniculate Nucleus of Marmoset Monkeys
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.1679-18.2018
Publisher version: https://doi.org/10.1523/JNEUROSCI.1679-18.2018
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10059233
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