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IDH mutant astrocytoma: biomarkers for prognostic stratification and the next frontiers

Brandner, S; Jaunmuktane, Z; (2019) IDH mutant astrocytoma: biomarkers for prognostic stratification and the next frontiers. [Editorial comment]. Neuropathology and Applied Neurobiology , 45 (2) pp. 91-94. 10.1111/nan.12521. Green open access

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Abstract

The discovery of IDH mutations in a subset of glioblastomas 10 years ago has fundamentally changed the approach of brain tumour diagnostics. Soon after this discovery, it emerged that low‐ and high‐grade oligodendrogliomas, diffuse and anaplastic astrocytomas, a proportion of glioblastomas and the now defunct oligoastrocytomas carry mutations in the IDH1 or IDH2 genes. Subsequently, the IDH‐mutant tumours were stratified with additional biomarkers, which has led to the definition of the WHO (2016) classes IDH‐mutant, 1p/19q codeleted (and TERT promoter mutant) oligodendroglioma and IDH‐mutant astrocytoma, with its characteristic loss of ATRX protein expression, assessed by immunostaining.

Type: Article
Title: IDH mutant astrocytoma: biomarkers for prognostic stratification and the next frontiers
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nan.12521
Publisher version: https://doi.org/10.1111/nan.12521
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10059209
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