UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Systematic classification of the His-Me finger superfamily

Jablonska, J; Matelska, D; Steczkiewicz, K; Ginalski, K; (2017) Systematic classification of the His-Me finger superfamily. Nucleic Acids Research , 45 (20) pp. 11479-11494. 10.1093/nar/gkx924. Green open access

[thumbnail of Systematic classification of the His-Me finger superfamily.pdf]
Preview
Text
Systematic classification of the His-Me finger superfamily.pdf - Published Version

Download (3MB) | Preview

Abstract

The His-Me finger endonucleases, also known as HNH or -metal endonucleases, form a large and diverse protein superfamily. The His-Me finger domain can be found in proteins that play an essential role in cells, including genome maintenance, intron homing, host defense and target offense. Its overall structural compactness and non-specificity make it a perfectly-tailored pathogenic module that participates on both sides of inter- and intra-organismal competition. An extremely low sequence similarity across the superfamily makes it difficult to identify and classify new His-Me fingers. Using state-of-theart distant homology detection methods, we provide an updated and systematic classification of His-Me finger proteins. In this work, we identified over 100 000 proteins and clustered them into 38 groups, of which three groups are new and cannot be found in any existing public domain database of protein families. Based on an analysis of sequences, structures, domain architectures, and genomic contexts, we provide a careful functional annotation of the poorly characterized members of this superfamily. Our results may inspire further experimental investigations that should address the predicted activity and clarify the potential substrates, to provide more detailed insights into the fundamental biological roles of these proteins.

Type: Article
Title: Systematic classification of the His-Me finger superfamily
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/nar/gkx924
Publisher version: https://doi.org/10.1093/nar/gkx924
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10058975
Downloads since deposit
71Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item