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Data of a Stiffness Softening Mechanism Effect on Proliferation and Differentiation of a Human Bone Marrow Derived Mesenchymal Stem Cell Line Towards the Chondrogenic and Osteogenic Lineages

Wu, L; Adrian, M; Wang, T; Liu, C; Darbyshire, A; Loizidou, M; Emberton, M; ... Song, W; + view all (2018) Data of a Stiffness Softening Mechanism Effect on Proliferation and Differentiation of a Human Bone Marrow Derived Mesenchymal Stem Cell Line Towards the Chondrogenic and Osteogenic Lineages. Data in Brief , 21 pp. 133-142. 10.1016/j.dib.2018.09.068. Green open access

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Abstract

This article contains data related to the research article entitled “Stiffness memory of indirectly 3D-printed elastomer nanohybrid regulates chondrogenesis and osteogenesis of human mesenchymal stem cells” [1] (Wu et al., 2018). Cells respond to the local microenvironment in a context dependent fashion and a continuous challenge is to provide a living construct that can adapt to the viscoelasticity changes of surrounding tissues. Several materials are attractive candidates to be used in tissue engineering, but conventional manufactured scaffolds are primarily static models with well-defined and stable stiffness that lack the dynamic biological nature required to undergo changes in substrate elasticity decisive in several cellular processes key during tissue development and wound healing. A family of poly (urea-urethane) (PUU) elastomeric nanohybrid scaffolds (PUU-POSS) with thermoresponsive mechanical properties that soften by reverse self-assembling at body temperature had been developed through a 3D thermal induced phase transition process (3D-TIPS) at various thermal conditions: cryo-coagulation (CC), cryo-coagulation and heating (CC + H) and room temperature coagulation and heating (RTC + H). The stiffness relaxation and stiffness softening of these scaffolds suggest regulatory effects in proliferation and differentiation of human bone-marrow derived mesenchymal stem cells (hBM-MSCs) towards the chondrogenic and osteogenic lineages.

Type: Article
Title: Data of a Stiffness Softening Mechanism Effect on Proliferation and Differentiation of a Human Bone Marrow Derived Mesenchymal Stem Cell Line Towards the Chondrogenic and Osteogenic Lineages
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dib.2018.09.068
Publisher version: https://doi.org/10.1016/j.dib.2018.09.068
Language: English
Additional information: Underer a Creative Commons license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Chemistry, biology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10058879
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