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Facile, Productive, and Cost-effective Synthesis of a Novel Tetrazine-based Iron Oxide Nanoparticle for Targeted Image Contrast Agents and Nanomedicines

Meloni, MM; Barton, S; Chivu, A; Kaski, JC; Song, W; He, T; (2018) Facile, Productive, and Cost-effective Synthesis of a Novel Tetrazine-based Iron Oxide Nanoparticle for Targeted Image Contrast Agents and Nanomedicines. Journal of Nanoparticle Research , 20 , Article 265. 10.1007/s11051-018-4370-8. Green open access

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Abstract

We have developed an operationally simple, time, and cost-effective protocol to produce a novel tetrazine-based iron oxide nanoparticle using commercially available and inexpensive materials. Our protocol proceeds at room temperature and uses hexafluorophosphate azabenzotriazole tetramethyl uronium, a well-known, widely used reagent for the large-scale industrial production of important pharmaceuticals. The nanoparticles obtained have a diameter range between 16 and 21 nm and showed no toxicity against endothelial cell lines. The tetrazine moiety on the nanoparticle surface could potentially allow further attachment of specific targeting vectors by using so-called copper-free click chemistry. We therefore anticipate that our protocol can represent a significant breakthrough in the future development and commercialization of improved, tissue-specific contrast agents and drug delivery for clinical diagnosis, monitoring and therapy of diseases at an asymptomatic stage.

Type: Article
Title: Facile, Productive, and Cost-effective Synthesis of a Novel Tetrazine-based Iron Oxide Nanoparticle for Targeted Image Contrast Agents and Nanomedicines
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11051-018-4370-8
Publisher version: https://doi.org/10.1007/s11051-018-4370-8
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Diagnosis, Magnetic resonance imaging, Iron oxide nanoparticles, Copper-free click chemistry, Bioconjugation, Synthesis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/10058878
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