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3D Registration of mpMRI for Assessment of Prostate Cancer Focal Therapy

Orczyk, C; Rosenkrantz, AB; Mikheev, A; Villers, A; Bernaudin, M; Taneja, SS; Valable, S; (2017) 3D Registration of mpMRI for Assessment of Prostate Cancer Focal Therapy. Academic Radiology , 24 (12) pp. 1544-1555. 10.1016/j.acra.2017.06.010. Green open access

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Abstract

RATIONAL AND OBJECTIVE: This study aimed to assess a novel method of three-dimensional (3D) co-registration of prostate magneticresonance imaging (MRI) examinations performed before and after prostate cancer focal therapy. MATERIAL AND METHODS: We developed a software platform for automatic 3D deformable co-registration of prostate MRI at different timepoints and applied this method to 10 patients who underwent focal ablative therapy . MRI examinations were performed preoperatively, aswell as 1 week and 6 months post treatment. Rigid registration served as reference for assessing co-registration accuracy and precision. RESULTS: Segmentation of preoperative and postoperative prostate revealed a significant postoperative volume decrease of the glandthat averaged 6.49 cc (P = .017). Applying deformable transformation based on mutual information from 120 pairs of MRI slices, werefined by 2.9 mm (max. 6.25 mm) the alignment of the ablation zone, segmented from contrast-enhanced images on the 1-week post-operative examination, to the 6-month postoperative T2-weighted images. This represented a 500% improvement over the rigid approach(P = .001), corrected by volume. The dissimilarity by Dice index of the mapped ablation zone using deformable transformation vs rigidcontrol was significantly (P = .04) higher at the ablation site than in the whole gland. CONCLUSION: Our findings illustrate our method’s ability to correct for deformation at the ablation site. The preliminary analysis sug-gests that deformable transformation computed from mutual information of preoperative and follow-up MRI is accurate in co-registration of MRI examinations performed before and after focal therapy. The ability to localize the previously ablated tissue in 3Dspace may improve targeting for image-guided follow-up biopsy within focal therapy protocols.

Type: Article
Title: 3D Registration of mpMRI for Assessment of Prostate Cancer Focal Therapy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.acra.2017.06.010
Publisher version: https://doi.org/10.1016/j.acra.2017.06.010
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Prostate cancer; focal therapy; longitudinal follow-up; MRI; image processing; three dimensional; biopsy; deformable registration
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10058800
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