UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation

Wood, RA; Bauza, M; Krupic, J; Burton, S; Delekate, A; Chan, D; O'Keefe, J; (2018) The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation. Nature , 554 (7690) pp. 102-105. 10.1038/nature25433. Green open access

[img]
Preview
Text
O'keefe_ppnature25433 jok corr.pdf - Accepted version

Download (315kB) | Preview

Abstract

Here we describe the honeycomb maze, a behavioural paradigm for the study of spatial navigation in rats. The maze consists of 37 platforms that can be raised or lowered independently. Place navigation requires an animal to go to a goal platform from any of several start platforms via a series of sequential choices. For each, the animal is confined to a raised platform and allowed to choose between two of the six adjacent platforms, the correct one being the platform with the smallest angle to the goal-heading direction. Rats learn rapidly and their choices are influenced by three factors: the angle between the two choice platforms, the distance from the goal, and the angle between the correct platform and the direction of the goal. Rats with hippocampal damage are impaired in learning and their performance is affected by all three factors. The honeycomb maze represents a marked improvement over current spatial navigation tests, such as the Morris water maze1,2,3, because it controls the choices of the animal at each point in the maze, provides the ability to assess knowledge of the goal direction from any location, enables the identification of factors influencing task performance and provides the possibility for concomitant single-cell recording.

Type: Article
Title: The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nature25433
Publisher version: http://dx.doi.org/10.1038/nature25433
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, ENTORHINAL CORTEX, RATS, REPRESENTATION, MEMORY, CELLS, MAP
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/10058638
Downloads since deposit
81Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item