Seddon, B;
Yates, AJ;
(2018)
The Natural History of Naive T Cells From Birth to Maturity.
Immunological Reviews
, 285
(1)
pp. 218-232.
10.1111/imr.12694.
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Abstract
Generating and maintaining a diverse repertoire of naive T cells is essential for protection against pathogens, and developing a mechanistic and quantitative description of the processes involved lies at the heart of our understanding of vertebrate immunity. Here, we review the biology of naive T cells from birth to maturity and outline how the integration of mathematical models and experiments has helped us to develop a full picture of their life histories.
| Type: | Article |
|---|---|
| Title: | The Natural History of Naive T Cells From Birth to Maturity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/imr.12694 |
| Publisher version: | https://doi.org/10.1111/imr.12694 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | T cells, thymic development, mathematical modelling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10058559 |
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