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Planar cell polarity in organ formation

Henderson, DJ; Long, DA; Dean, CH; (2018) Planar cell polarity in organ formation. Current Opinion in Cell Biology , 55 pp. 96-103. 10.1016/j.ceb.2018.06.011. Green open access

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Abstract

The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.

Type: Article
Title: Planar cell polarity in organ formation
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceb.2018.06.011
Publisher version: https://doi.org/10.1016/j.ceb.2018.06.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10058454
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