UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Characterizing the skull base in craniofacial microsomia using principal component analysis

Schaal, SC; Ruff, C; Pluijmers, BI; Pauws, E; Looman, CWN; Koudstaall, MJ; Dunaway, DJ; (2017) Characterizing the skull base in craniofacial microsomia using principal component analysis. International Journal of Oral and Maxillofacial Surgery , 46 (12) pp. 1656-1663. 10.1016/j.ijom.2017.07.008. Green open access

[thumbnail of FinalversionIJOMSmanuscript_Schaal_Characterising the skull base.pdf]
Preview
Text
FinalversionIJOMSmanuscript_Schaal_Characterising the skull base.pdf - Accepted Version

Download (739kB) | Preview

Abstract

The aim of this study was to compare the anatomical differences in the skull base between the affected and non-affected side in patients with craniofacial microsomia (CFM), and to compare the affected and non-affected sides with measurements from a normal population. Three-dimensional computed tomography scans of 13 patients with unilateral CFM and 19 normal patients (age range 7–12 years) were marked manually with reliable homologous landmarks. Principal component analysis (PCA), as part of a point distribution model (PDM), was used to analyse the variability within the normal and preoperative CFM patient groups. Through analysis of the differences in the principal components calculated for the two groups, a model was created to describe the differences between CFM patients and normal age-matched controls. The PDMs were also used to describe the shape changes in the skull base between the cohorts and validated this model. Using thin-plate splines as a means of interpolation, videos were created to visualize the transformation from CFM skull to normal skull, and to display the variability in shape changes within the groups themselves. In CFM cases, the skull base showed significant asymmetry. Anatomical areas around the glenoid fossa and mastoid process showed the most asymmetry and restriction of growth, suggesting a pathology involving the first and second pharyngeal arches.

Type: Article
Title: Characterizing the skull base in craniofacial microsomia using principal component analysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijom.2017.07.008
Publisher version: http://dx.doi.org/10.1016/j.ijom.2017.07.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Dentistry, Oral Surgery & Medicine, Surgery, craniofacial microsomia, skull base, principal component analysis, facial asymmetry, BRANCHIAL ARCH SYNDROME, HEMIFACIAL MICROSOMIA, CLASSIFICATION, PATHOGENESIS, DISTRACTION, MORPHOLOGY, DEFORMITY, FEATURES, 1ST
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10058377
Downloads since deposit
190Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item