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Supracellular contraction at the rear of cell groups drives collective chemotaxis

Shellard, A; Szabó, A; Trepat, X; Mayor, R; (2018) Supracellular contraction at the rear of cell groups drives collective chemotaxis. Science , 362 (6412) pp. 339-343. 10.1126/science.aau3301. Green open access

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Abstract

Collective cell chemotaxis, the directed migration of cell groups along gradients of soluble chemical cues, underlies various developmental and pathological processes. Here we use neural crest cells, a migratory embryonic stem cell population whose behavior has been likened to malignant invasion, to study collective chemotaxis in vivo. Studying Xenopus and zebrafish, we show that the neural crest exhibits a tensile actomyosin ring at the edge of the migratory cell group that contracts in a supracellular fashion. This contractility is polarized during collective cell chemotaxis: it is inhibited at the front but persists at the rear of the cell cluster. The differential contractility drives directed collective cell migration ex vivo and in vivo through intercalation of rear cells. Thus, in neural crest cells, collective chemotaxis works by rear wheel drive.

Type: Article
Title: Supracellular contraction at the rear of cell groups drives collective chemotaxis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.aau3301
Publisher version: https://doi.org/10.1126/science.aau3301
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10058375
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