Dawson, SJ;
Bowl, MR;
(2019)
Age-Related Hearing Loss.
Cold Spring Harbor perspectives in medicine
, 9
, Article a033217. 10.1101/cshperspect.a033217.
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Abstract
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive hearing impairment leads to social isolation and is also associated with comorbidities, such as frailty, falls, and late-onset depression. Moreover, there is a growing evidence linking it with cognitive decline and increased risk of dementia. Given the large social and welfare burden that results from ARHL, and because ARHL is potentially a modifiable risk factor for dementia, there is an urgent need for therapeutic interventions to ameliorate age-related auditory decline. However, a prerequisite for design of therapies is knowledge of the underlying molecular mechanisms. Currently, our understanding of ARHL is very limited. Here, we review recent findings from research into ARHL from both human and animal studies and discuss future prospects for advances in our understanding of genetic susceptibility, pathology, and potential therapeutic approaches in ARHL.
Type: | Article |
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Title: | Age-Related Hearing Loss |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1101/cshperspect.a033217 |
Publisher version: | http://dx.doi.org/10.1101/cshperspect.a033217 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute |
URI: | https://discovery.ucl.ac.uk/id/eprint/10058367 |
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