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Can we reconcile ‘the obesity paradox’ with recent cardiovascular outcome trials in diabetes?

Jamieson, A; Finer, N; (2017) Can we reconcile ‘the obesity paradox’ with recent cardiovascular outcome trials in diabetes? Clinical Obesity , 7 (5) pp. 255-259. 10.1111/cob.12217. Green open access

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Abstract

Several recent cardiovascular outcome trials (CVOT) in patients with type 2 diabetes have shown benefit in terms of both weight loss and cardiovascular benefit. At the same time a number of epidemiological studies have shown that a body mass index above 25 kg/m² may be beneficial - the so-called ‘obesity paradox’. We discuss whether these CVOT support the potential benefits of intentional or therapeutic weight loss, but conclude that such conclusions would be simplistic and will require trials specifically designed for this purpose.

Type: Article
Title: Can we reconcile ‘the obesity paradox’ with recent cardiovascular outcome trials in diabetes?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/cob.12217
Publisher version: https://doi.org/10.1111/cob.12217
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/10058243
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