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Local transformations of the hippocampal cognitive map

Krupic, J; Bauza, M; Burton, S; O'Keefe, J; (2018) Local transformations of the hippocampal cognitive map. Science , 359 (6380) pp. 1143-1145. 10.1126/science.aao4960. Green open access

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Abstract

Grid cells are neurons active in multiple fields arranged in a hexagonal lattice and are thought to represent the “universal metric for space.” However, they become nonhomogeneously distorted in polarized enclosures, which challenges this view. We found that local changes to the configuration of the enclosure induce individual grid fields to shift in a manner inversely related to their distance from the reconfigured boundary. The grid remained primarily anchored to the unchanged stable walls and showed a nonuniform rescaling. Shifts in simultaneously recorded colocalized grid fields were strongly correlated, which suggests that the readout of the animal’s position might still be intact. Similar field shifts were also observed in place and boundary cells—albeit of greater magnitude and more pronounced closer to the reconfigured boundary—which suggests that there is no simple one-to-one relationship between these three different cell types.

Type: Article
Title: Local transformations of the hippocampal cognitive map
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.aao4960
Publisher version: http://dx.doi.org/10.1126/science.aao4960
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, MEDIAL ENTORHINAL CORTEX, HEAD-DIRECTION CELLS, LANDMARK STABILITY, PATH-INTEGRATION, SPATIAL MAP, PLACE CELLS, GRID CELLS, MODEL, REPRESENTATIONS, RATS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: https://discovery.ucl.ac.uk/id/eprint/10058176
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