Whitaker, D;
Batuecas, M;
Ricci, P;
Larrosa, I;
(2017)
A Direct Arylation-Cyclisation Reaction for the Construction of Medium-Sized Rings.
Chemistry - A European Journal
, 23
(52)
pp. 12763-12766.
10.1002/chem.201703527.
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Abstract
A strategy for assembling biaryls linked through a medium‐sized ring is herein presented. π‐Complexation of fluoroarenes to chromium tricarbonyl activates the molecule towards both C−H activation and nucleophilic aromatic substitution without covalently altering the molecular connectivity of the arene. The construction of bridged biaryl molecules with 6–10‐membered core rings is achieved through a one‐pot C−H arylation/nucleophilic aromatic substitution sequence. The methodology is applicable to the synthesis of heterocyclic as well as fully carbocyclic rings.
| Type: | Article |
|---|---|
| Title: | A Direct Arylation-Cyclisation Reaction for the Construction of Medium-Sized Rings |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/chem.201703527 |
| Publisher version: | https://doi.org/10.1002/chem.201703527 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Biaryls, C−H activation, homogeneous catalysis, medium-ring compounds, organometallic chemistry |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10057977 |
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