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Coping-Style Behavior Identified by a Survey of Parent-of-Origin Effects in the Rat

Mont, C; Hernandez Pilego, P; Cañete, T; Oliveras, I; Río-Álamos, C; Blázquez, G; López-Aumatell, R; ... Mott, R; + view all (2018) Coping-Style Behavior Identified by a Survey of Parent-of-Origin Effects in the Rat. G3: Genes, Genomes, Genetics , 8 (10) pp. 3283-3291. 10.1534/g3.118.200489. Green open access

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Abstract

In this study we investigate the effects of parent of origin on complex traits in the laboratory rat, with a focus on coping style behavior in stressful situations. We develop theory, based on earlier work, to partition heritability into a component due to a combination of parent of origin, maternal, paternal and shared environment, and another component that estimates classical additive genetic variance. We use this theory to investigate the effects on heritability of the parental origin of alleles in 798 outbred heterogeneous stock rats across 199 complex traits. Parent-of-origin-like heritability was on average 2.7-fold larger than classical additive heritability. Among the phenotypes with the most enhanced parent-of-origin heritability were 10 coping style behaviors, with average 3.2-fold heritability enrichment. To confirm these findings on coping behaviour, and to eliminate the possibility that the parent of origin effects are due to confounding with shared environment, we performed a reciprocal F1 cross between the behaviourally divergent RHA and RLA rat strains. We observed parent-of-origin effects on F1 rat anxiety/coping-related behavior in the Elevated Zero Maze test. Our study is the first to assess genetic parent-of-origin effects in rats, and confirm earlier findings in mice that such effects influence coping and impulsive behavior, and suggest these effects might be significant in other mammals, including humans.

Type: Article
Title: Coping-Style Behavior Identified by a Survey of Parent-of-Origin Effects in the Rat
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1534/g3.118.200489
Publisher version: https://doi.org/10.1534/g3.118.200489
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Behavior, coping-style, epigenetics, heritability, imprinting, multiparental, parent of origin, rat
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10057959
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