Fluid biomarkers for microglial activation and axonal injury in multiple sclerosis

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Fluid biomarkers for microglial activation and axonal injury in multiple sclerosis

Zetterberg, H; (2017) Fluid biomarkers for microglial activation and axonal injury in multiple sclerosis. Acta Neurologica Scandinavica , 136 (s201) pp. 15-17. 10.1111/ane.12845. Green open access

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Abstract

Although it is clear that the immune system is an important disease driver in multiple sclerosis (MS), it is presently unknown what initiates the process. Infections have been mentioned as potential triggers, which is specifically dealt with in other articles of this volume. Here, I give an overview of two fluid biomarkers that reflect key elements of the MS process: microglial activation (cerebrospinal fluid [CSF] sTREM2) and axonal injury (CSF and serum/plasma neurofilament light). I review recent data on how these markers are altered in MS, how they change in relation to disease progression and treatment and, finally, how they can be used as tools in MS research.

Type:	Article
Title:	Fluid biomarkers for microglial activation and axonal injury in multiple sclerosis
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1111/ane.12845
Publisher version:	http://doi.org/10.1111/ane.12845
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	axonal injury, biomarkers, cerebrospinal fluid, microglia, multiple sclerosis, plasma serum
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI:	https://discovery.ucl.ac.uk/id/eprint/10057939

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