UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Domain-specific characterisation of early cognitive impairment following spontaneous intracerebral haemorrhage

Banerjee, G; Summers, M; Chan, E; Wilson, D; Charidimou, A; Cipolotti, L; Werring, DJ; (2018) Domain-specific characterisation of early cognitive impairment following spontaneous intracerebral haemorrhage. Journal of the Neurological Sciences , 391 pp. 25-30. 10.1016/j.jns.2018.05.015. Green open access

[img]
Preview
Text
Banerjee_neuropsych_ICH_JNeurolSci_REV-CLEAN.pdf - Accepted version

Download (478kB) | Preview

Abstract

Cognitive deficits after spontaneous intracerebral haemorrhage (ICH) are common and result in functional impairment, but few studies have examined deficits across cognitive domains in the subacute phase. This study aims to describe the cognitive profile following acute ICH and explore how cerebral amyloid angiopathy (CAA) may impact performance. We retrospectively reviewed 187 consecutive patients with ICH (mean age 58.9 years, 55.6% male) with available imaging and neuropsychological data (median 12 days after stroke). In our cohort, 84% (n = 158) were impaired in at least one cognitive domain and 65% (n = 122) in two or more domains. Deficits in non-verbal IQ (76.6%), information processing speed (62.4%) and executive functions (58.1%) were most common. Patients with lobar ICH (n = 92) had more deficits in naming and visual perception than those with non-lobar ICH, but not in adjusted analyses. Patients with probable CAA (n = 21) had more deficits in verbal IQ, visual perception and executive functions than those without probable CAA; in adjusted analyses, probable CAA predicted impairment in verbal IQ (OR 38.6, 95% CI 3.2 to 465.4, p = 0.004) and executive function (OR 3.4, 95% CI 1.0 to 11.7, p = 0.050). We conclude that cognitive deficits following ICH are common across domains, and that those with CAA appear to have a different cognitive profile. Replication of this work in larger cohorts will be important for confirming and further quantifying these observations.

Type: Article
Title: Domain-specific characterisation of early cognitive impairment following spontaneous intracerebral haemorrhage
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jns.2018.05.015
Publisher version: https://doi.org/10.1016/j.jns.2018.05.015
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cerebral amyloid angiopathy, Small vessel disease, Intracerebral haemorrhage, Cognitive impairment, Stroke
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/10057879
Downloads since deposit
86Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item