UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Functionalized MoS_{2}-nanosheets for targeted drug delivery and chemo-photothermal therapy

Zhang, X; Wu, J; Williams, GR; Niu, S; Qian, Q; Zhu, L-M; (2019) Functionalized MoS_{2}-nanosheets for targeted drug delivery and chemo-photothermal therapy. Colloids Surf B Biointerfaces , 173 pp. 101-108. 10.1016/j.colsurfb.2018.09.048. Green open access

[thumbnail of COLSUB-D-18-01059R2.pdf]
Preview
Text
COLSUB-D-18-01059R2.pdf - Accepted Version

Download (13MB) | Preview

Abstract

Molybdenum disulfide (MoS_{2}) has been extensively explored for biomedical applications due to its excellent photothermal conversion ability. In this paper, we report a nanoplatform based on folic acid (FA) targeted dual-stimuli responsive MoS2 nanosheets and explore this for the treatment of FA-receptor positive human breast cancer. The nanocomposites generated had a uniform diameter (ca. 133 nm), and could be loaded with the anti-cancer drug doxorubicin (DOX) to a high capacity (151.4 mg/g). The release of DOX was greatly accelerated at pH 5.0 as compared to pH 7.4. In addition, it was found that drug release is enhanced under near infrared laser (NIR) irradiation, showing that the composites can be used as dual responsive systems, with DOX release controllable through pH or NIR irradiation. MTT assays and confocal experiments showed that the MoS2-based nanoplatform could selectively target and kill FA-positive MDA-MB-231 cells (a human breast cancer cell line). The platform also allowed the combination of chemotherapy and photothermal therapy, which led to synergistic effects superior to either monotherapy. The functionalized MoS2 nanoplatform developed in this work hence could be a potent system for targeted drug delivery and synergistic chemo-photothermal cancer therapy.

Type: Article
Title: Functionalized MoS_{2}-nanosheets for targeted drug delivery and chemo-photothermal therapy
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.colsurfb.2018.09.048
Publisher version: https://doi.org/10.1016/j.colsurfb.2018.09.048
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Drug delivery, MoS_{2}, Synergistic chemo-photothermal therapy, Targeted
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10057864
Downloads since deposit
397Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item